Have you already seen this error with OfflineIMAP and Sqlite3?

 Creating new Local Status db for Local-Gmail:INBOX-journal
 ERROR: While attempting to sync account 'GMail'
  file is encrypted or is not a database

Oh god, one of your databases is corrupted. This corruption is usually caused by an interruption during processing an account. But don't worry, the fix is quite simple.

First go on .offlineimap/Account-<YourAccountName>/LocalStatus-sqlite, open the file INBOX with sqlite3 and type pragma integrity_check; (and press Enter):

SQLite version 3.7.14.1 2012-10-04 19:37:12
Enter ".help" for instructions
Enter SQL statements terminated with a ";"
sqlite> pragma integrity_check;

Now you can quit with .quit and restart offlineimap.

Enjoy!